Uncle Jesse is not perfect
Wow, this is simultaneously the grossest and funniest talk show appearance I've ever seen. Belly buttons, in general, are gross. As this clip illustrates, John Stamos has, hands down, the World's Weirdest Belly Button, yet Conan and Tom Selleck don't exactly have any bragging rights either. Their reactions to the Stamos hole are priceless. Selleck is probably huddled in the fetal position under a table somewhere right now, clutching his rifle.
Someone's had his Chic-lets whitened recently too.